The question “What can change the nature of a man?” emerges perhaps half-way through Planescape: Torment. From the intense focus that it garners whenever the game is discussed, you’d expect it to be pushed a bit harder than that over the course of the game. It is important, yes, but it is not everything.
I think it’s a shame to fixate on it so much, because I think the game has so much more to offer than… just this.